Eli Lilly says an experimental drug slows Alzheimer's worsening

2025-01-19 08:17:33 source: category:News

WASHINGTON — Eli Lilly and Co. said Wednesday its experimental Alzheimer's drug appeared to slow worsening of the mind-robbing disease in a large study.

In the 18-month trial, people in the early stages of Alzheimer's who received infusions of donanemab showed 35% less decline in thinking skills compared to those given a dummy drug, Lilly announced in a press release.

The drug is designed to target and clear away a sticky protein called beta-amyloid that builds up into brain-clogging plaques that are one hallmark of Alzheimer's.

A similar amyloid-targeting drug, Eisai and Biogen's Leqembi, recently hit the market with similar evidence that it could modestly slow Alzheimer's — and also some safety concerns, brain swelling or small brain bleeds.

Donanemab also comes with that risk. Lilly said in its study, the brain side effects caused the deaths of two participants and a third also died after a serious case.

The preliminary study results haven't been vetted by outside experts. Indianapolis-based Lilly plans to release more details at an international Alzheimer's meeting this summer and is seeking Food and Drug Administration approval of the drug.

More:News

Recommend

1 dead, 2 children injured in wrong-way crash; driver suspected of DWI: Reports

A woman was killed and two children were injured in Houston, Texas after a pickup truck heading the

Goal of the year? Manchester United's Alejandro Garnacho with insane bicycle kick

We are less than halfway through the English Premier League season, but we may have just witnessed t

Terry Venables, the former England, Tottenham and Barcelona coach, has died at 80

LONDON (AP) — Terry Venables, a former England soccer player who led the national team to the semifi